Glucuronosyltransferase wikipedia
WebIrinotecan, sold under the brand name Camptosar among others, is a medication used to treat colon cancer, and small cell lung cancer. For colon cancer it is used either alone or with fluorouracil. For small cell lung cancer it is used with cisplatin. It is given intravenously.. Common side effects include diarrhea, vomiting, bone marrow suppression, hair loss, … Uridine 5'-diphospho-glucuronosyltransferase (UDP-glucuronosyltransferase, UGT) is a microsomal glycosyltransferase (EC 2.4.1.17) that catalyzes the transfer of the glucuronic acid component of UDP-glucuronic acid to a small hydrophobic molecule. This is a glucuronidation reaction. Alternative names: … See more Glucuronosyltransferases are responsible for the process of glucuronidation, a major part of phase II metabolism. Arguably the most important of the Phase II (conjugative) enzymes, UGTs have been the subject of … See more A deficiency in the bilirubin specific form of glucuronosyltransferase is thought to be the cause of Gilbert's syndrome, which is characterized by unconjugated hyperbilirubinemia. It is also associated with Crigler–Najjar syndrome, … See more Human genes which encode UGT enzymes include: • B3GAT1, B3GAT2, B3GAT3 • UGT1A1, UGT1A3 See more • Glucuronosyltransferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH) See more
Glucuronosyltransferase wikipedia
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WebAug 6, 2024 · (Glucuronosyltransferase - Wikipedia, the free encyclopedia) A deficiency in the bilirubin specific form of glucuronosyltransferase is thought to be the cause of Gilbert's syndrome, which is characterized by unconjugated hyperbilirubinemia. (Glucuronosyltransferase - Wikipedia, the free encyclopedia) WebEste artigo resulta, no todo ou em parte, de uma tradução do artigo «Glucuronosyltransferase» na Wikipédia em inglês, na versão original. Você pode incluir conceitos culturais lusófonos de fontes em português com referências e inseri-las corretamente no texto ou no rodapé.Também pode ou colaborar em outras traduções. …
WebUridine 5'-diphospho-glucuronosyltransferase (UDP-glucuronosyltransferase, UGT) is a microsomal glycosyltransferase (EC 2.4.1.17) that catalyzes the transfer of the glucuronic acid component of UDP-glucuronic acid to a small hydrophobic molecule. This is a glucuronidation reaction. WebHuman UDP-glucuronosyltransferase (UGT) exists as a superfamily of 22 proteins, which are divided into 5 families and 6 subfamilies on the basis of sequence identity. Members of the UGT1A and 2B subfamilies play a key role in terminating the biological actions and enhancing the renal elimination of non-polar (lipophilic) drugs from all ...
WebUDP-glucuronosyltransferases (UGTs) are important phase II metabolic enzymes responsible for approximately 40-70% of endo and xenobiotic reactions. It catalyzes … WebMiners JO, Mackenzie PI, Knights KM (2010) The prediction of drug-glucuronidation parameters in humans: UDP-glucuronosyltransferase enzyme-selective substrate and inhibitor probes for reaction phenotyping and in vitro-in vivo extrapolation of drug clearance and drug-drug interaction potential. Drug Metab Rev 42(1):196–208
WebUridine diphosphate glucuronosyltransferase is localized to the endoplasmic reticulum (ER) and spans the membrane with a type I topology. The putative transmembrane domain is located near the carboxyl terminus of the protein such that only a small portion of the protein resides in the cytosol. This cytosolic tail is believed to contain an ER ...
Webテンプレートを表示. グルクロン酸転移酵素 (または、グルクロノシルトランスフェラーゼ、 英: Glucuronosyl transferase )は、肝臓において グルクロン酸抱合 を行う 酵素 。. … taxi fronteras sataxi from zante airport to laganasWebNov 3, 2015 · name: glucuronoxylan glucuronosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of glucuronate to the xylan backbone of glucuronoxylan molecule." [PMID:18980649] is_a: GO:0015020 ! glucuronosyltransferase activity AmiGO GO:0080116 Gene Ontology Home. The contents … taxi frontenasWebDec 1, 2024 · The UDP-glucuronosyltransferase (UGT) family of enzymes play a central role in the metabolism and detoxification of a wide range of endogenous and exogenous … the chronicles of prydain and earthseaWebNational Center for Biotechnology Information taxi from zurich to baselUGT2B7 (UDP-Glucuronosyltransferase-2B7) is a phase II metabolism isoenzyme found to be active in the liver, kidneys, epithelial cells of the lower gastrointestinal tract and also has been reported in the brain. In humans, UDP-Glucuronosyltransferase-2B7 is encoded by the UGT2B7 gene. the chronicles of narnia part 3WebUGT2B15. UDP-glucuronosyltransferase 2B15 is an enzyme that in humans is encoded by the UGT2B15 gene. [3] [4] The UGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. UGT2B8 demonstrates reactivity with estriol. the chronicles of prydain old mass markets